Studying the Aerodynamic Characteristics of the Macrotech and Evaluation of the Possibilities of Its Use for Dynamic Aerosol Scintigraphy

Introduction: The leading protective mechanism of the lungs is processes deposition inhaled substances and mucociliary clearance (MCC), optimal method for studying which dynamic radioaerosol scintigraphy. are not available on market. applicant in this regard a number characteristics radiopharmaceutical from albumin, produced Russian Federation under brand name Macrotech (M). It used perfusion scintigraphy to verify primarily pulmonary embolism its ability study inhalants MCC has been studied. Purpose: To aerodynamic properties M dispersion determine possibilities use order assess MCC. Material methods: M, assessment significantly depends, we studied particles different states, them shape morphology. An ultrasonic inhaler TuR USI-50 (Germany) generated an aerosol suspension distilled water. air, laser spectrometry was using Spraytec Malvern Instruments system (Great Britain). protein content initial dispersible aerosol, collected form condensate, determined Immulite 2000 XPi immunochemical analyzer (Siemens, USA).The morphology were scanning electron microscopy using. Results: indicated that involved dynamics movement airflow flight water by inhaler. dispersity averaged about 5 μm did depend concentration intensity rate set characterized complex roughness. Conclusion: However, final verdict requires direct preparation.